韩楠玉

发布时间:2020-04-08    点击:

云南师范大学生命科学学院研究生导师简况表

韩楠玉

副教授 硕士导师



主要招生专业

生物化学与分子生物学(微生物方向)



主要研究方向

1.蛋白质理性设计优化

2.病毒靶点及新药研发


       

学历研究简历:(从本科起序)

20059- 20097 中国农业大学 生物学院 学士

2009年7月- 2014年4月 新加坡南洋理工大学 生物学院 博士


代表论文和著作

1.Enheng Zhu, Xia Xiang, Sidi Wan, Huabiao Miao, Nanyu Han*, Zunxi Huang*, Discovery of the key mutation site influencing the thermostability of Thermomyces lanuginosus lipase by Rosetta design programs. International Journal of Molecular Sciences (2022) 23: 8963.

2.Nanyu Han#, Minyuan Tang#, Sidi Wan, Zhanbao Jiang, Yong Yue, Xiangui Zhao, Jinrun Yang, Zunxi Huang*, Surface charge engineering of Thermomyces lanuginosus lipase improves enzymatic activity and biodiesel synthesis. Biotechnology Letters (2021) 43: 1403-1411.

3.Huabiao Miao, Yu Ma, Yuanyuan Zhe, Xianghua Tang, Qian Wu, Zunxi Huang*, Nanyu Han*, Improving the thermostability of a fungal GH11 xylanase via fusion of a submodule (C2) from hyperthermophilic CBM9_1-2. International Journal of Molecular Sciences (2021) 23:463.

4.Nanyu Han, Justin Tze Yang Ng, Yanpeng Li, Yuguang Mu*, Zunxi Huang*, Plasticity of the 340-Loop in influenza neuraminidase offers new insight for antiviral drug development. International Journal of Molecular Sciences (2020) 21:5655.

5.Zhanbao Jiang, Chengbo Zhang, Minyuan Tang, Bo Xu, Lili Wang, Wen Qian, Jiandong He, Zhihong Zhao, Qian Wu, Yuelin Mu, Junmei Ding, Rui Zhang, Zunxi Huang*, Nanyu Han*, Improving the thermostability of Rhizopus Chinensis lipase through site-directed mutagenesis based on B-factor analysis. Frontiers in Microbiology (2020) 11:346.

6.Nanyu Han#, Yu Ma#, Yuelin Mu, Xianghua Tang, Junjun Li, Zunxi Huang*, Enhancing thermal tolerance of a fungal GH11 xylanase guided by B-factor analysis and multiple sequence alignment. Enzyme and Microbial Technology (2019) 131:109422.

7.Nanyu Han#, Huabiao Miao#, Tingting Yu, Bo Xu, Yunjuan Yang, Qian Wu, Rui Zhang, Zunxi Huang*, Enhancing thermal tolerance of Aspergillus niger PhyA phytase directed by structural comparison and computational simulation. BMC Biotechnology (2018) 18:36.

8.Nanyu Han#, Huabiao Miao#, Junmei Ding, Junjun Li, Yuelin Mu, Junpei Zhou, Zunxi Huang*, Improving the thermostability of a fungal GH11 xylanase via site-directed mutagenesis guided by sequence and structural analysis. Biotechnology for Biofuels (2017) 10:133.

9.Nanyu Han, Yuguang Mu, Huabiao Miao, Yunjuan Yang, Qian Wu, Junjun Li, Junmei Ding, Bo Xu, Zunxi Huang*, The 340-cavity in neuraminidase provides new opportunities for influenza drug development: A molecular dynamics simulation study. Biochemical and Biophysical Research Communications (2016), 470(1):130-136.

10.Nanyu Han, Yuguang Mu*, Locking the 150-cavity open: In silico design and verification of influenza neuraminidase inhibitors. PLoS ONE (2013) 8:8.

11.Nanyu Han, Yuguang Mu*, Plasticity of 150-Loop in influenza neuraminidase explored by Hamiltonian replica exchange molecular dynamics simulations. PLoS ONE (2013) 8:4.

12.Nanyu Han, Xuewei Liu, Yuguang Mu*, Exploring the mechanism of Zanamivir resistance in a neuraminidase mutant: A molecular dynamics study. PLoS ONE (2012) 7:9.

13.Jiahai Shi#, Nanyu Han#, Liangzhong Lim, Shixiong Lua, J. Sivaraman, Lushan Wang, Yuguang Mu*, Jianxing Song*, Dynamically-driven inactivation of the catalytic machinery of the SARS 3C-Like protease by the N214A mutation on the extra domain. PLoS Computational Biology (2011) 7:2.


获奖成果:

1.指导曹艳、李志怡、崔克玲、滕雨荷同学获得第四届全国大学生生命科学竞赛(2020年)全国一等奖

2.指导顾明霞同学获得2022届云南师范大学本科生优秀毕业论文


主持的国家级或其他项目

1.国家自然科学基金32160217):基于Ser/Thr替换的木聚糖酶XynCDBFV耐热机制及优化策略研究,经费:34万,2022.01-2025.12(主持)

2.国家自然科学基金31660240):流感病毒神经氨酸酶NACa2+的互作机制及药物靶点研究,经费38万,2017.01-2020.12.(主持)

3.云南省自然科学面上项目(202201AT070033):计算机辅助设计提高脂肪酶TLL耐热性及耐热机制研究,10万,2022.06-2025.05(主持)

4.云南省自然科学青年项目(2016FD018):高通量筛选抗流感病毒中药组分及作用机制研究,6万,2016.10-2019.09(主持)

5.云南师范大学优秀青年学者项目,第五批,2021.01-2023.12(主持)


近三年主讲课程

1.现代微生物学及研究方法

2.生物学实验

3.解密传染病


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