主要研究方向：

1.药食植物活性成分

2.特殊生境次级代谢产物化学结构和修饰

3.天然产物抗菌靶点与作用机制

4.活性成分靶向递送与控制释放

学历及研究简历：（从本科起正序）

1. 2009年9月-2013年9月：西北农林科技大学，本科，林产化工

2. 2015年9月-2018年6月：西北农林科技大学，硕士研究生，应用化学

3. 2018年9月-2022年6月：云南大学，博士研究生，有机化学（天然药物化学方向）

4. 2022年7月-2024年10月：云南大学化学博士后流动站，博士后，药用植物活性成分与抗菌机制研究

5. 2024年12月-至今：云南师范大学生命科学学院，从事教学科研工作

代表论文和著作：

1. Li-Li Chen^#, Min Liu^#, Tian-Zhen Xie, Wu-Feng Yang, Ming Gong, Yun-Xiu Cheng, Shuang Long Yang*, Wei-You Xie*, Zhao-Jie Wang*. Mining Bioactive Compounds against Drug-Resistant Microorganisms from Ethnomedicine: Examples of 32 Ethnic Medicines in Yunnan.Pharmacognosy Research.2026, 18(2):1-28.（共同通讯作者）

2. Chen Li-Li, Yang Shuang-Long, Wei-You Xie, Shi Nian, Wang Zhao-Jie*.Comparison of chemical constituents in Lysimachiaspecies and their antimicrobial activity for extending the shelf life of foods. Food Chemistry: X.2025:102086. (唯一通讯作者).

3. Xie Wei-You, Chen Li-Li, Min Liu, Yang Shuang Long, Gong Ming, Wang Zhao-Jie*. Chemical constituents of Rabdosia species and their antimicrobial and antioxidant activities in extending meat shelf life. Journal of Food Science.2025, 90(7):70387. (唯一通讯作者).

4. Wang Zhao-Jie, Zhu Yan-Yan, Bai Li-Yu, Yu-Duan, Xiao-Dong Luo*. A new therapeutic strategy for infectious diseases against intracellular multidrug-resistant bacteria. Journal of Controlled Release.2024, 375, 467-477.（第一作者）

5. Wang Zhao-Jie, Huang Huan, Yan-Yan Zhu, Liu Tie, Zhou Zhong Shun, He Xing-Chao, Xiao-Dong Luo*. Anti-microbial ingredients of Zanthoxylum motuoenseand potential in fresh pork meat preservation. Heliyon.2024, e22963. （第一作者）

6. Wang Zhao-Jie, Chen Yi-Chi, Zou Feng-Cai, Yan Qin, Zhao Yun-li, Luo Xiao-Dong*. Phytochemical analysis and anti-Ascaris suumactivity of different Zanthoxylumspeciesin vitroandin vivo.Journal of Agricultural and Food Chemistry.2023, 71, 5219-5229. （第一作者）

7. Wang Zhao-Jie,Jin Dan Ni, Zhou Yin, Sang Xu Yan, Zhu Yan-Yan, Luo Xiao-Dong*. Bioactivity ingredients of Chaenomeles speciosaagainst microbes: characterization by LC-MS and activity evaluation.Journal of Agricultural and Food Chemistry.2021, 69, 4686−4696. （第一作者）

8. Wang Zhao-Jie, Zhou Ying, Si Xiao-Long, Xiao Xia, Luo Xiao-Dong*. Comparison of chemical constituents in diverse zanthoxylumherbs, and evaluation of their relative antibacterial and nematicidal activity. Food Bioscience.2021, 40:101206. （第一作者）

9. Wang Zhao-Jie, Zhu Yan-Yan, Yi Xing, Zhou Zhong-Sun, He Yin-Jie, Zhou Ying, Zhao Yun-Li, Luo Xiao-Dong*. Bioguided isolation, identification and activity evaluation of antifungal compounds from Acorus tatarinowii Schott.Journal of Ethnopharmacology.2020, 261, 113119. （第一作者）

10. Wang Zhao-Jie,Hu Bai; Lu Chun-Bo, Hou Chun-Yan; Qiu Yuan-Hao, Peng Zhang, Jin you Duan^*, Hai bo Mu^*. Light controllable chitosan micelles with ROS generation and essential oil release for the treatment of bacterial biofilm.Carbohydrate Polymers.2019, 205: 533–539. （第一作者）

11. Wang Zhao-Jie, Qiu Yuan Hao, Hou Chun Yan, Wang Dong-Dong; Sun Fei-Fei, Haibo Mu; Jin you Duan^*. Synthesis of hyaluronan-amikacin conjugate and its bactericidal activity against intracellular bacteria in vitroandin vivo.Carbohydrate Polymers.2018，181：132-140.（第一作者）

12. Wen-Biao Zu^#,Wang Zhao-Jie^#, Dong-Mei Tang, Qin-Yu Lu, Yan-Yan Zhu, Zhong-Shun Zhou, Mei-Zhen Wei,Xiao-Dong Luo^*. Prosapogenin CP4 and ursolic acid from Eriocapitella rivularisinhibit fluconazole-resistant Candida albicans synergistically by regulating Ras/cAMP/PKA pathway. Phytomedicine, 2026,155:158142.（共同第一）

13. Mei Li-Na^#,Wang Zhao-Jie^#et al. 4-Hydroxyboesenbergin B of Alpinia japonicaprotected gastrointestinal tract by inhibiting Vancomycin-resistantenterococcusand balancing intestinal microbiota. Journal of Ethnopharmacology,2025: 119737. （共同第一）

14. Jiang Yue-Ming^#,Wang Zhao-Jie^#et al. Eucalyptus globulusresidues inhibiting both MRSA and VRE in vitro and in vivo. Industrial Crops and Products,2025, 226: 120725. （共同第一）

15. Duan Yu^#,Wang Zhao-Jie^#et al. Anti-Candida albicanseffect and mechanism of Pachysandra axillarisFranch.Journal of Ethnopharmacology,2025, 340: 119284. （共同第一）

16. Shi Nian^#,Wang Zhao-Jie^#et al. New resorcylic acid derivatives of Lysimachia tengyuehensisagainst MRSA and VRE by interfering with bacterial metabolic imbalance.European Journal of Medicinal Chemistry.2024,277: 116714. （共同第一）

17. Tang Dong-Mei^#,Wang Zhao-Jie^#et al. Activity of the caged xanthone morellic acid against Vancomycin-resistant Enterococcusinfection by targeting the bacterial membrane. Journal of Natural Products,2024, 87(10): 2366-2375. （共同第一）

18. Lu Qin-Yu^#,Wang Zhao-Jie^#et al. Two new abietane diterpenoids from Caryopteris trichosphaera.Fitoterapia,2024, 179: 106269. （共同第一）

19. Liu Tie^#,Wang Zhao-Jie^#et al. Curcusinol from the fruit of Carex baccanswith antibacterial activity against multidrug-resistant strains.Journal of Ethnopharmacology.2024, 318: 116892. （共同第一）

20. Bai Li-Yu^#,Wang Zhao-Jie^#et al. 6-Methoxyldihydrochelerythrine chloride inhibiting intra and extracellular drug-resistant bacteria. ACS Infectious Diseases.2024, 10(9): 3430-3439.（共同第一）

21. Shen Jia-Shan^#,Wang Zhao-Jie^#et al. Antifungal bioactivity of Sarcococca hookeriana var. digyna Franch. against fluconazole-resistant Candida albicans in vitro and in vivo. Journal of Ethnopharmacology.2024: 118473. （共同第一）

22. Shi Yang-Zhu^#,Wang Zhao-Jie^#et al. Anti-MRSA mechanism of spirostane saponin in Rohdea pachynemaFT Wang & tang. Journal of Ethnopharmacology.2024, 331: 118327. （共同第一）

23. Zhou Zhong-Shun^#,Wang Zhao-Jie^#et al. Three new ent-kaurane diterpenes with antibacterial activity from Sigesbeckia orientalis.Molecules,2024, 29(19): 4631. （共同第一）

24. Lu Qing-Yu^#,Wang Zhao-Jie^#et al. Diterpenoids of Caryopteris trichosphaeraW. W. Sm. inhibiting MRSA and VRE in vitro and in vivo. Journal of Ethnopharmacology.2024, 337:118805. （共同第一）

25. Wei Mei-Zhen^#,Wang Zhao-Jie^#et al. Oleanolic acid derivatives against drug-resistant bacteria and fungi by multi-targets to avoid drug resistance. European Journal of Medicinal Chemistry,2024, 280: 116940. （共同第一）

26. Zhu Yan-Yan^#,Wang Zhao-Jie^#et al. A dual mechanism with H₂S inhibition and membrane damage of morusin from Morus alba Linn. against MDR-MRSA. Bioorganic & Medicinal Chemistry.2024, 97: 117544. （共同第一）

27. Zeng Qi^#,Wang Zhao-Jie^#et al. Phytochemical and anti-MRSA constituents of Zanthoxylum nitidum.Biomedicine & Pharmacotherapy.2022, 112758. （共同第一）

28. 抗耐药菌授权专利：罗晓东，王兆杰等.一种活性化合物及其提取方法和应用、药物组合物及其应用.2022.授权号：CN 113637021 B.

29. Ma Dan-Yu^#;Wang Zhao-Jie^#; C. Y C; Q. Z H; W. H; Z.Y-Y; Luo Xiao-Dong*. Antifungal compounds of Chinese prickly ash against drug-resistant Candida albicans.Food Chemistry: X.2022, 15: 100400. （共同第一）

30. Xu Xiang-Juan^#;Wang Zhao-Jie^#; Qin Xu-Jie, et al. Phytochemical and Antibacterial Constituents of Edible Globe AmaranthFlower against Pseudomonas aeruginosa.Chemistry & Biodiversity.2022, e202200139. （共同第一）

31. Zhu Meng^#;Wang Zhao-Jie^#; He Ying-Jie; Qin, Yan; Zhou, Ying; Qi, Zi-Heng; Luo, Xiao-Dong*. Bioguided isolation, identification and bioactivity evaluation of anti-MRSA constituents from Morus albaLinn.Journal of Ethnopharmacology.2021, 281:114542.（共同第一）

主持的国家级或其他项目：

1. 2026/1–2030/12，云南省“兴滇英才青年人才专项”，“云麻等五种云南特色药用植物抗耐药菌活性天然产物研究”，50万，主持，在研。

2. 2025/1-2029/12，云南师范大学“联大学者第六层次”人才引进专项，80万，主持，在研。

3. 2024/1–2026/12,国家自然科学基金青年项目（82304328），“三种药用植物中抗耐药菌活性化合物构效关系和作用机制研究”，30万，主持，在研。

4. 2022/10-2024/12，中国博士后基金面上项目（2022M722709），“抗MRSA、VRE植物新活性成分的发现、构效优化与作用机制”，8万，主持，已结题。

5. 2022/8-2024/8，云南省博士后科学基金面上项目，“两种云南特色药用植物抗MRSA活性天然产物研究”，2万，主持，已结题。

6. 2025/1-2028/12，国家自然科学基金面上项目（32470423）, “四个活性灯台碱的生物合成途径解析及异源重构”, 50

7. ,参与，在研。

8. 2023/1-2026/12,国家自然科学基金联合重点支持项目（U2202212）, “抗耐药菌植物新活性成分的发现、构效优化与作用机制研究”，240万，参与，在研。

9. 2022/1-2025/12，国家自然科学基金面上项目（32170405），“两种药用植物中抗MRSA活性天然产物研究”，58万，参与，已结题。

10. 2022/1-2025/12，国家自然科学基金地区项目（82160673），“三株稀有放线菌中抗耐药病原菌的活性新化合物挖掘”，36万，参与，已结题。

主讲课程：（研究生、本科）

本科课程：有机化学、有机化学实验